Ferrer's next tournament was the 2010 Mutua Madrileña Madrid Open, where he was seeded ninth. In the first round, he defeated Jérémy Chardy 6-3, 7-6(2) and defeated Marcos Baghdatis 1-6, 6-3, 7-5 after fending off a match point. He then defeated Marin Čilić 6-3, 6-2 to advance to the quarterfinals. There he, for the second successive time, beat world No. 4 Andy Murray 7-5, 6-3. In the semifinals Ferrer lost to world No.1 Roger Federer in three sets. Ferrer's next tournament was the 2010 French Open, where he entered as a favorite. he began his campaign with a 6-1, 6-3, 6-1 victory over french wildcard David Guez, and then defeated Xavier Malisse 6-2, 6-2, 2-0 ret. In the third round. he fell to surprise semifinalist Jurgen Melzer 4-6, 0-6, 6-7(1).
Ferrer's next tournament was the 2010 Wimbledon Championships, where he is the 9th seed. In the first round, he defeated Nicolas Kiefer 6-4, 6-2, 6-3 and then defeated Florent Serra in the second round 6-4, 7-5, 6-7(6), 6-3. In the third round, he defeated Jeremy Chardy 7-5, 6-3, 4-6, 3-6, 7-5, with Chardy serving for the match at 5-4 in the fifth. In the fourth round, he was defeated by Robin Soderling 2-6, 7-5, 2-6, 6-3, 5-7, despite being two points away from the match on two occasions.
